Cerebral Venous Sinus Thrombosis is not Significantly Linked to COVID-19 Vaccines or Non-COVID Vaccines in a Large Multi-State Health System

June 16 2021

To assess the association of COVID-19 vaccines and non-COVID-19 vaccines with cerebral venous sinus thrombosis (CVST). Materials and method: We retrospectively analyzed a cohort of 771,805 vaccination events across 266,094 patients in the MayoClinic Health System between 01/01/2017and 03/15/2021. The primary outcome was a positive diagnosis of CVST, identified either by the presence of a corresponding ICD code or by an NLP algorithm which detected positive diagnosis of CVST within free-text clinical notes. For each vaccine we calculated the relative risk by dividing the incidence of CVST in the 30 days following vaccination to that in the 30 days preceding vaccination.


Colin Pawlowski, John Rincón-Hekking, Samir Awasthi, Viral Pandey, Patrick Lenehan, AJ Venkatakrishnan, Sairam Bade, John C. O'Horo, Abinash Virk, Melanie D. Swift, Amy W. Williams, Gregory J. Gore, Andrew D. Badley, John Halamka, Venky Soundararajan

nference, Cambridge, MA 02142, USA nference Labs, Bengaluru, KA 560017, India Mayo Clinic, Rochester, MN 55905, USA

Mayo Clinic


Correspondence to:

Venky Soundararajan (venky@nference.net)