January 13, 2026
What happens to weight after we stop prescribing GLP-1 therapies?
Venky Soundararajan
GLP-1 receptor agonists (GLP-1RAs) such as semaglutide and tirzepatide have transformed obesity care and weight management, delivering unprecedented levels of weight loss in real-world practice. Several studies have demonstrated reversal of weight loss and other cardiometabolic benefits after patients discontinue GLP-1RAs.